This document is targeted at virtualization, security, and network architects interested in deploying cloud and software-defined data center (SDDC) architectures based on VMware network virtualization solutions (VMware NSX) with the Trend Micro Deep Security Platform. It is an undisputed fact that virtualization has a remarkable impact on our data center computing environment. The cost savings from consolidation that were the initial focus of the virtualization journey have now been long realized by many organizations. These organizations have moved on to achieve benefits such as incredible flexibility and speed in application delivery that virtualization enables. We have seen the overall category of server virtualization mature while the other critical data center components such as networking technologies and security services have not advanced at a similar pace. Networking technologies in particular had remained relatively static until the start of the software-defined data center era.